American journal of physiology. Gastrointestinal and liver physiologyAnimalsHistone DeacetylasesHepatocytesObesityMale
Loss of histone deacetylase 4 in hepatocytes perturbs lipid metabolism and insulin signaling in mice with diet-induced obesity.
Hyungryun Jang, Minkyung Bae, Yoojin Lee, Hyunju Kang, Mi-Bo Kim, Siqi Hu, Olivia Corvino, Jaeeun Lee, Hayoung Woo, Victoria Kostour, William Odell, Adam Kim, Young-Ki Park, Ji-Young Lee
Published: 202610.1152/ajpgi.00225.2025
Abstract
Epigenetic regulations link environmental factors to the development of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). We determined the role of hepatocyte histone deacetylase 4 (HDAC4) in the pathogenesis of MASLD. Mal…
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