American journal of physiology. Endocrinology and metabolismAnimalsMiceKnockoutMaleLipid Metabolism
Global loss of selenocysteine lyase in mice drives lipid accumulation in brown adipocytes.
Briana K Shimada, Ashley N Ogawa-Wong, Antonio G Soares, Kayla A Hallam, Princess J D Santiago, Kaitlyn Saelua, Kescher K Nakahara-Akita, Daniel J Torres, John D Brockman, Suguru Kurokawa, Kris L Ewell, Miyoko T Bellinger, Pamela Toh, Gabriela Lagatta Pamplona Remedios, Naghum Alfulaij
Published: 202610.1152/ajpendo.00213.2025
Abstract
The enzyme selenocysteine (Sec) lyase (SCLY) decomposes Sec, releasing selenide for the synthesis of selenoproteins, which contain Sec in their primary structure and participate in strong redox reactions, maintaining redox balance. We previously show…
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