American journal of physiology. Cell physiologyHumansIon ChannelsMechanotransductionCellularAnimals
PIEZO1 channel mechanosensing in hepatobiliary physiology and disease.
Charalampos Konstantinou, Shaili K Patel, Patricia Lalor, J Bernadette Moore, Lee D Roberts, Naima Endesh, Tze M Wah, Adel Samson, Abdul R Hakeem, Kondragunta R Prasad, David J Beech, Laeticia Lichtenstein
Published: 202610.1152/ajpcell.00782.2025
Abstract
The hepatobiliary system is constantly exposed to dynamic mechanical forces, including fluid shear stress, bile canaliculi pressure, and extracellular matrix stiffness. Although traditionally studied for its metabolic and detoxifying functions, it is…
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