American journal of physiology. Cell physiology
Central activation of Chaperone-Mediated Autophagy Reduces Appetite by Fine-Tuning Hypothalamic Amino Acid Pools: New Insights from Fish.
Steffi Reji, Emilio J Vélez, Ayelén M Blanco, Cécile Heraud, Vincent Véron, Karine Dias, Alexandre Stella, Odile Burlet-Schiltz, Simon Schnebert, Jérôme Roy, Florian Beaumatin, Beth Cleveland, José L Soengas, Iban Seiliez
Published: 202610.1152/ajpcell.00765.2025
Abstract
Chaperone-Mediated Autophagy (CMA) is a key lysosomal proteolytic pathway essential for cellular homeostasis and metabolism, with dysfunction linked to various human diseases. While extensively studied in humans and mice, CMA was only recently identi…
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