American journal of physiology. Cell physiologyAquaporin 2AnimalsReceptorsG-Protein-CoupledKidney Tubules
GPR39 activation inhibits AQP2 trafficking and alters cytoskeletal organization.
Mackenzie K Kui, Jessica J Zhang, Ibrahim A Ahmed, Shishir Kumar Patel, Tara Fallah Rastegar, Hamid Rabb, Jennifer L Pluznick
Published: 202610.1152/ajpcell.00748.2025
Abstract
G protein-coupled receptor 39 (GPR39) is an orphan receptor that is highly expressed in renal collecting duct principal cells. GPR39 activation in vivo leads to reduced urinary concentration capacity. In this study, we used mpkCCD cells, a model of p…
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