American journal of physiology. Cell physiologyAnimalsMiceInbred mdxValeratesMechanistic Target of Rapamycin Complex 1
β-Hydroxy-β-methylbutyrate enhances fast-twitch muscle and mitochondrial function, histopathology and mTORC1 signalling in the mdx dystrophic mouse.
Nicholas Giourmas, Hannah Lalunio, Chuhui Wu, Ryan Bagaric, Memphis Calzoni, Craig A Goodman, Alan Hayes
Published: 202610.1152/ajpcell.00722.2025
Abstract
Duchenne muscular dystrophy (DMD) is one of the most severe forms of inheritable muscular dystrophies, caused by a genetic mutation resulting in the loss of dystrophin. Dystrophin loss initiates a cascade of negative mechanistic changes in skeletal m…
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