American journal of physiology. Cell physiologyHumansExtracellular MatrixTendonsFibroblastsAdaptation
Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit.
Ask Møbjerg, Danielle Steffen, Peter Schjerling, Jens Rithamer Jakobsen, Anja Jokipii-Utzon, Mykhailo Y Batiuk, Konstantin Khodosevich, Michael Rindom Krogsgaard, Valerio Izzi, Abigail L Mackey, Michael Kjaer, Ching-Yan Chloé Yeung
Published: 202510.1152/ajpcell.00700.2025
Abstract
Mechanical loading drives structural and functional improvements in muscle and tendon, protecting against injury at their interface, at the myotendinous junction (MTJ), and within the tendon matrix. However, the early cellular and molecular events th…
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