American journal of physiology. Cell physiologyPentacyclic TriterpenesAnimalsTriterpenesMuscular AtrophyMuscle Fibers
Celastrol and Cblin peptide activation of IGF-1 signaling prevents microgravity-induced atrophy in rat L6 myotubes.
Junsoo Park, Anayt Ulla, Takayuki Uchida, Siyun Lee, Haruka Tsuda, Tomoko Ishige Suzuki, Toko Hashizume, Akira Higashibata, Rackhyun Park, Takeshi Kobayashi, Masahiro Sokabe, Inho Choi, Takeshi Nikawa
Published: 202610.1152/ajpcell.00348.2025
Abstract
This study investigated the efficacy of two natural compounds-celastrol, a heat shock protein (HSP) inducer, and Cblin peptide, a ubiquitination inhibitor-in counteracting muscle atrophy under real microgravity conditions. Both agents independently a…
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