Annual review of physiology
The Proton-Activated Chloride Channel: Molecular Identification, Structure, and Role in Organelle Physiology.
Kevin Hong Chen, Tatsuya Hagino, Zhaozhu Qiu
Published: 202510.1146/annurev-physiol-022724-105357
Abstract
In 2019, a novel membrane protein, PAC (also known as TMEM206), was identified as the long-sought molecular carrier of an acid- or proton-activated chloride current observed ubiquitously in mammalian cells. This discovery has led to rapid progress in…
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