Annual review of medicineHumansT-LymphocytesRegulatoryNeoplasmsTumor Microenvironment
Regulatory T Cell Depletion in Cancer: Challenges, Opportunities, and Future Directions for Antibody Development.
Mariela Navarrete, Cristobal Costoya, Felipe Galvez-Cancino, Karl S Peggs, Aurelien Marabelle, Sergio A Quezada
Published: 202610.1146/annurev-med-043024-123559
Abstract
Regulatory T cells (Tregs) accumulate in the tumor microenvironment, where they suppress antitumor immunity and hinder immunotherapy efficacy. Antibody-mediated Treg depletion has emerged as a promising strategy, but its clinical translation has been…
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