Journal for immunotherapy of cancerHumansCancer-Associated FibroblastsEpithelial-Mesenchymal TransitionLung NeoplasmsTransforming Growth Factor beta
Reciprocal regulation of hMENA and TGF-β signaling in cancer-associated fibroblasts promotes EMT, immunosuppression, poor prognosis, and ICT resistance in NSCLC.
Roberta Melchionna, Francesca Di Modugno, Anna Di Carlo, Lorenzo D'Ambrosio, Belinda Palermo, Annalisa Tocci, Francesca Paolini, Isabella Sperduti, Giulia Campo, Riccardo Tajè, Filippo Gallina, Paolo Visca, Daniel D'Andrea, Paola Nistico
Published: 202610.1136/jitc-2025-013098
Abstract
BACKGROUND: Cancer-associated fibroblasts (CAFs) significantly impact cancer progression and CAF subtypes are key determinants of response to immune checkpoint therapy (ICT). The transforming growth factor-β (TGF-β) signaling is a main pathway in pro…
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