Journal for immunotherapy of cancerTumor MicroenvironmentAnimalsMiceMelanomaExperimental
Reprogramming the melanoma tumor immune microenvironment via combinatorial signal 2/3 gene delivery.
Kathryn M Luly, Xin Ming Matthew Zhou, Sachin S Surwase, Erick E Rocher, Jack Kollings, Charles Lu, Elizabeth Will, Qingfeng Zhu, Robert A Anders, Jordan J Green, Stephany Y Tzeng, Joel C Sunshine
Published: 202610.1136/jitc-2025-012856
Abstract
INTRODUCTION: An adaptive immune response to cancer requires three main signals: antigen presentation and recognition ("signal 1"), costimulation ("signal 2"), and secreted immunostimulatory cytokines ("signal 3"). Expression of these signals in tumo…
Preview only. Read the full abstract at the source