Gut
CD48 is a novel immune checkpoint on tumour-associated macrophages in hepatocellular carcinoma.
Gege Shi, Yang Xiao, Zhaozhao Li, Yueyuan Qiu, Yueyuan Zhou, Jieyu Zhang, Weina Li, Lei He, Fei Xie, Haiyan Cao, Duo Yu, Haichen Du, Guodong Li, Wangqian Zhang, Shuning Wang
Published: 202610.1136/gutjnl-2025-336744
Abstract
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapeutic options. Despite promising immunotherapy, response rates remain suboptimal. Tumour-associated macrophages (TAMs) constitute a pivotal component…
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