Gut
Peginterferon alpha-2a add-on to siRNA JNJ-73763989 in untreated patients with HBeAg-positive chronic hepatitis B virus (HBV) infection: the phase 2 REEF-IT study.
Patrick T F Kennedy, Scott Fung, Maria Buti, Gurdal Yilmaz, Wan-Long Chuang, Tarik Asselah, Masayuki Kurosaki, John Jezorwski, Vladislav Klyashtornyy, Thierry Verbinnen, Thomas Naoki Kakuda, Oliver Lenz, Carine Guinard-Azadian, Michael Biermer
Published: 202510.1136/gutjnl-2025-336592
Abstract
BACKGROUND: In the hepatitis B e antigen positive (HBeAg+) chronic infection disease phase, approved treatments have limited effects on hepatitis B surface antigen (HBsAg) and HBeAg. OBJECTIVE: The phase 2 REEF-IT study (NCT04439539) assessed safety,…
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