Gut
Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn's disease.
Longyuan Zhou, Jing Nie, Zhiyin Feng, Rongchang Li, Pingxin Zhang, Sinan Lin, Yao Zhang, Florian Rieder, Changhao Chen, Minhu Chen, Ren Mao
Published: 202510.1136/gutjnl-2025-336415
Abstract
BACKGROUND: Intestinal fibrosis, a hallmark complication of Crohn's disease (CD), frequently progresses to stricture formation and surgical intervention. Fibroblast metabolic reprogramming is important in organ fibrosis. However, its role in intestin…
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