GutSTAT1 Transcription FactorReperfusion InjuryAnimalsSignal TransductionHistone-Lysine N-Methyltransferase
SMYD2-mediated methylation of STAT1 protects against hepatic ischaemia/reperfusion injury by blocking JAK-STAT1 signalling pathways.
Zhiyong Yang, Yufeng Hu, Chunyong Yang, Yujie Li, Xueyuan Zhong, Zhenfu Wu, Yingjie Zuo, Shanyu Gan, Lin Chen, Ziyang Zeng, Guiheng Qi, Yuanbao Chen, Junjie Zhou, Xiao-Jing Zhang, Hongliang Li
Published: 202610.1136/gutjnl-2025-336400
Abstract
BACKGROUND: The JAK/STAT pathway plays a pivotal role in hepatic ischaemia/reperfusion (I/R) injury, a serious perioperative complication. Although signal transducers and activators of transcription 1 (STAT1) activation is known to drive I/R-induced…
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