Gut
A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis.
Yu Chen, Wanneng Li, Shuhui Wang, Han Wang, Jiaxin Xu, Meiping Yu, Lijia Wang, Zhenghao Ye, Xinmei Yan, Zhuoying Lin, Ping Han, Fang Xiao, Wei Yan, Dean Tian, Yu Lei
Published: 202510.1136/gutjnl-2025-336363
Abstract
BACKGROUND: Autoimmune hepatitis (AIH) is characterised by death of hepatocytes and chronic inflammation. Patients with deleterious variants in A20 are identified with AIH presentations and immune activation. However, it remains unclear how A20 dysre…
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