Gut
Indole-3-propionic acid links gut dysfunction to diabetic retinopathy: a biomarker and novel therapeutic approach.
Ram Prasad, Yvonne Adu-Rutledge, Borhane Ziani, Jason L Floyd, Edgar L Ready, Sarbodeep Paul, Fadeela Sheini, Rati Sharma, Robert F Rosencrans, Sergio Li Calzi, Micheli Severo Sielski, Nicholas G Medawar, Roshan Dutta, Emory Brennis Johnson, Xiaoping Qi
Published: 202610.1136/gutjnl-2025-336180
Abstract
BACKGROUND: Both host and microbe metabolism of tryptophan (Trp) is altered in diabetes; however, the molecular mechanisms are incompletely understood. OBJECTIVE: We used strategies to increase either angiotensin converting enzyme-2 (ACE-2) dependent…
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