Gut
Crosstalk between liver sinusoidal endothelial cells and hepatocytes via IL-1α-IL1R1 axis exacerbates ischaemia/reperfusion injury in aged livers.
Yasong Liu, Tingting Wang, Feng Zhang, Xuying Liu, Zhongying Hu, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Qiang You, Zhengqi Wu, Jia Yao, Yingcai Zhang, Shuhong Yi, Hua Li, Qi Zhang
Published: 202510.1136/gutjnl-2025-335964
Abstract
BACKGROUND: With population ageing, elderly patients account for a growing proportion of hepatic surgery recipients. Hepatic ischaemia-reperfusion injury (HIRI) is a major cause of postoperative liver dysfunction, particularly in aged livers, yet its…
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