Gut
PDE5A+ cancer-associated fibroblasts enhance immune suppression in gastric cancer.
Kewei Wang, Chen-Jun Xie, Zheng Ding, Ting Shan, Zhangfeng Zhong, Feng-Lai Yuan, Jun-Jie Wu, Zheng-Dong Yuan, Chengjia Qian, Lihua Yu, Yankui Liu, Jianqing Cheng, Qing-Lin Zhang, Wei Liu, Yong Zhao
Published: 202510.1136/gutjnl-2025-335794
Abstract
BACKGROUND: Gastric cancer (GC) ranks among the most prevalent lethal tumours globally. Cancer-associated fibroblasts (CAFs) are pivotal in creating an immunosuppressive tumour microenvironment (TME) in GC. OBJECTIVE: Identifying a critical subpopula…
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