Biochemistry. BiokhimiiaAnimalsLipofuscinLipid PeroxidationRatsHumans
Mitochondrial Lipid Peroxidation Initiates Rapid Accumulation of Lipofuscin in Cultured Cells.
He Huan, Alisa A Panteleeva, Ruben A Simonyan, Armine V Avetisyan, Konstantin G Lyamzaev, Boris V Chernyak
Published: 202510.1134/S0006297925602606
Abstract
Activation of lipid peroxidation (LPO) in the mitochondria of rat H9c2 cardiomyoblasts and human fibroblasts by the cystine transport inhibitor erastin or glutathione peroxidase 4 inhibitor RSL3 was accompanied by rapid (18 h) accumulation of lipofus…
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