Biochemistry. BiokhimiiaHumansHeLa CellsMethyltransferasesSpliceosomesRNA Splicing
Activity of METTL4 Methyltransferase Is Crucial for Maintaining Optimal Splicing Efficiency in HeLa S3 Cells.
Anastasiia K Bolikhova, Andrey I Buyan, Maria A Khokhlova, Sofia S Mariasina, Anton R Izzi, Alexander Y Rudenko, Marina V Serebryakova, Alexander M Mazur, Olga A Dontsova, Petr V Sergiev
Published: 202510.1134/S0006297925602382
Abstract
Methyltransferases that modify spliceosomal small nuclear RNAs (snRNAs) play a crucial role in the cell by ensuring proper maturation of snRNAs, which is essential for optimal function of spliceosome. In this study, we investigated the enzyme METTL4,…
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