Microbiology spectrum
The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development.
Jon U Hansen, Rakel Arrazuria, Jennifer L Hoover, Bernhard Kerscher, Douglas L Huseby, Sylvie Sordello, Philip Gribbon, Yojana Gadiya, Leonie von Berlin, Gesa Witt, Natália Tassi, Frederikke Rosenborg, Sha Cao, Isabelle Bekeredjian-Ding, Otto Lindahl
Published: 202610.1128/spectrum.03464-25
Abstract
The growing threat of antimicrobial resistance highlights the urgent need for new treatment strategies. Reliable animal data are essential to accelerate antibiotic development, and standardized murine infection models, like the neutropenic mouse pneu…
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