Microbiology spectrum
A two-step screen identifies a small molecule that disrupts membrane voltage and is effective against growing and persister gram-negative bacteria.
Ciara K Asamoto, Calvin A Ewing, Christian T Meyer, Samual C Allgood, Matthew J G Eldridge, Donald Evans, Toni A Nagy, Grace L Christensen, Amy L Crooks, Daqing Jiang, Sophie Helaine, Corrella S Detweiler
Published: 202510.1128/spectrum.03217-25
Abstract
New antibiotics effective against gram-negative bacteria are difficult to discover because many small molecules are excluded by the cell envelope. There is a growing consensus that the proton motive force (PMF) represents a key target for the develop…
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