Genome sequences of two highly colistin-resistant Pseudomonas aeruginosa clinical isolates from the cystic fibrosis lung.

The genomes of two highly colistin-resistant strains of Pseudomonas aeruginosa (MICs ≥ 1,024 mg/mL) isolated from cystic fibrosis lung infections were sequenced and analyzed. Genes associated with colistin resistance (pmrAB, phoPQ) showed unique mutations compared to other strains with similar resistance levels.