mBio
A CDK-4EBP1 signaling axis drives HSV-1 replication and underscores a druggable pathway for potent antiviral intervention.
Krishnaraju Madavaraju, Tejabhiram Yadavalli, Sudhanshu Kumar Singh, Chandrashekhar D Patil, Hemant Borase, Deepak Shukla
Published: 202610.1128/mbio.03741-25
Abstract
Herpes simplex virus type 1 (HSV-1) poses a persistent public health challenge, particularly due to the emergence of drug-resistant strains and the limited efficacy of current monotherapies. Through an unbiased multi-omic approach, we identify a prev…
Preview only. Read the full abstract at the source