mBio
Reprogramming Listeria monocytogenes flavin metabolism to improve its therapeutic safety profile and broaden innate T-cell activation.
Victoria Chevée, Mariya Lobanovska, Rafael Rivera-Lugo, Leslie Güereca, Ying Feng, Andrea Anaya-Sanchez, Jesse Garcia Castillo, Austin M Huckins, Edward E Lemmens, Chris S Rae, Jonathan W Hardy, Russell Carrington, Jonathan W Kotula, Daniel A Portnoy
Published: 202510.1128/mbio.03652-25
Abstract
Listeria monocytogenes is a facultative intracellular bacterial pathogen that is a potent inducer of cell-mediated immunity, which has led to the development of attenuated, Listeria-based cancer vaccines. L. monocytogenes strains, such as live-attenu…
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