mBio
Candida albicans-induced ubiquitination of EGFR reveals novel host-fungal interaction pathways.
Léa Lortal, James S Griffiths, Emily L Priest, Alexander Kempf, Olivia K A Paulin, Nicole O Ponde, Antzela Tsavou, Don N Wickramasinghe, Andrew Donkin, Claire M Lyon, Olivia W Hepworth, Jonathan P Richardson, Julian R Naglik
Published: 202610.1128/mbio.03448-25
Abstract
Candida albicans causes severe mucosal and systemic infections, with hypha formation playing a key role in its virulence. Hyphal invasion via endocytosis is mediated predominantly through interactions between Als3p and the epidermal growth factor rec…
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