mBio
PA-X 122V broadly determines the host shutoff activity of influenza A viruses.
Yuying Yang, Mengmeng Xu, Naixin Zhang, Qinhao Yu, Yunfei Wan, Chengzhi Xu, Yunpu Wu, Fei Meng, Yan Chen, Huanliang Yang, Guohua Deng, Jianzhong Shi, Li Jiang, Chuanling Qiao, Hualan Chen
Published: 202510.1128/mbio.03433-25
Abstract
Multiple genes are involved in the pathogenicity of influenza A virus. Our previous study reported two naturally occurring amino acid mutations in the polymerase acidic (PA) protein as crucial determinants of the virulence of Eurasian avian-like H1N1…
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