mBio
The Pseudomonas aeruginosa DedA protein PA4029 is an undecaprenyl phosphate flippase important for polymyxin resistance.
Davide Sposato, Yi Wang, Xinye Zhang, Ludovica Rossi, Stefania De Chiara, Flaviana Di Lorenzo, Livia Leoni, Giordano Rampioni, Paolo Visca, Jani R Bolla, Francesco Imperi
Published: 202610.1128/mbio.02408-25
Abstract
Undecaprenyl phosphate (C55-P) is a critical lipid carrier required for the transport of cell envelope precursors across the cytoplasmic membrane in bacteria. Recent studies have identified proteins of the DedA family and DUF368 domain family as C55-…
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