Journal of virology
Key residues in SARS-CoV-2 NSP3 hypervariable region are necessary to modulate early stress granule activity.
R Elias Alvarado, Kumari G Lokugamage, Dimitriya Garvanska, Leah K Estes, Yani Ahearn, Alyssa M McLeland, Arian Moayyed, Jennifer Chen, Blanca Lopez Mendez, Jessica A Plante, Kenneth S Plante, Bryan A Johnson, Jakob Nilsson, Vineet D Menachery
Published: 202610.1128/jvi.02006-25
Abstract
Antagonism of the host responses that limits viral replication is critical to the success of infection. Recently, we identified that the hypervariable region (HVR) of SARS-CoV-2 NSP3 binds to FXR1 and disrupts stress granule formation during the earl…
Preview only. Read the full abstract at the source