Journal of clinical microbiology
Differentiating mpox infection and vaccination using a validated multiplex orthopoxvirus IgG serology assay.
Jonathan C Reed, Cecilia Downs, Kaden McAllister, Clarice Mauer, Christopher L McClurkan, Donna Wilson, Kate Holzhauer, Jane A Dickerson, Chase A Cannon, Tara M Babu, Matthew R Golden, David M Koelle, Alexander L Greninger
Published: 202510.1128/jcm.01548-25
Abstract
The resurgence of monkeypox virus (MPXV) has increased demand for validated serological assays to assess exposure and immunity. Cross-reactivity among orthopoxviruses, stemming from high sequence conservation, complicates distinguishing antibody resp…
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