Infection and immunity
Human body temperature cues widespread changes in virulence gene expression in uropathogenic Escherichia coli.
Carolyn A Dehner, Isidora N Stankovic, Madeleine Sutherland, Lou Ann Bierwert, Kalina P Dimova, Stylianos P Scordilis, Daniel M Stoebel, Christine A White-Ziegler
Published: 202510.1128/iai.00422-25
Abstract
As a bacterial pathogen enters a human host, it immediately encounters a temperature upshift to 37°C. Mimicking the early hours of infection, we analyzed the transcriptome and proteome of uropathogenic Escherichia coli CFT073 initially grown at 23°C,…
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