Infection and immunity
Intralysosomal pathogens differentially influence the proteolytic potential of their niche.
Lauren E Bird, Bangyan Xu, David R Thomas, Erin N S McGowan, Patrice Newton, Nichollas E Scott, Malcolm J McConville, Laura E Edgington-Mitchell, Hayley J Newton
Published: 202510.1128/iai.00270-25
Abstract
Avoiding lysosomal degradation is vital to the success of intracellular pathogens. The Gram-negative bacterium Coxiella burnetii and protozoan parasites of the Leishmania genus are unique in being able to replicate within the mature phagolysosomal co…
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