Antimicrobial agents and chemotherapy
Exploring T. cruzi IMPDH as a promising target through Chagas Box screening and AVN-944 inhibition.
Angel Lobo-Rojas, Letícia Marchese, Amanda G Eufrasio, Gabriel T D Souza, Michelle F Catelli, Jessica D N Faria, Artur T Cordeiro
Published: 202610.1128/aac.01210-25
Abstract
Chagas disease, caused by Trypanosoma cruzi, remains a leading cause of heart failure in Latin America, with current treatments limited to acute-phase efficacy, significant toxicity, and emerging resistance. Inosine monophosphate dehydrogenase (IMPDH…
Preview only. Read the full abstract at the source