Antimicrobial agents and chemotherapy
Identification and characterization of a novel inhibitor of influenza A virus that acts by blocking nucleoprotein oligomerization.
Vincent H J Leonard, Dianna B Vidales, Benjamin R Taft, Matthew J Hesse, Patrick S Lee, Mulugeta Mamo, Dirksen E Bussiere, Karen C Wolff, Kelli L Kuhen, Laura Wedel, Ellena Growcott, Colin Osborne, Cassio P Octaviani, Pinghan Huang, Chien-Te Kent Tseng
Published: 202510.1128/aac.01149-25
Abstract
Influenza A virus (IAV) causes annual epidemics and sporadic pandemics of acute respiratory infections resulting in significant morbidity and mortality. Although approved influenza antivirals (e.g., oseltamivir and baloxavir) exist, concerns persist…
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