Antimicrobial agents and chemotherapy
Pharmacokinetics and safety of fosfomycin and flomoxef administered as part of neonatal sepsis treatment (NeoSep1 Part 1).
Adrie Bekker, Navarat Panjasawatwong, Louise F Hill, Wolfgang Stohr, A Sarah Walker, Sally Ellis, Angela Dramowski, Andrew Whitelaw, Christina Obiero, James A Berkley, Alexander Makazi, Sithembiso Velaphi, Reenu Thomas, Petronella Magagula, Ilhaam Abrahams
Published: 202510.1128/aac.01126-25
Abstract
Neonatal doses for the off-patent antibiotics fosfomycin and flomoxef, which offer coverage against many extended-spectrum beta-lactamase (ESBL)-producing organisms, are based on limited data. We performed a pharmacokinetic (PK) and safety study of f…
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