Antimicrobial agents and chemotherapy
A mechanism-based pharmacokinetic/pharmacodynamic analysis of polymyxin B-based combination therapy against carbapenem-resistant Klebsiella pneumoniae isolates with diverse phenotypic and genotypic resistance mechanisms.
Ramya Mahadevan, Estefany Garcia, Rajnikant Sharma, Hongqiang Qiu, Ahmed Elsheikh, Robert Parambi, Cely Saad Abboud, Fernando Pasteran, Maria Soledad Ramirez, Keith S Kaye, Robert A Bonomo, Gauri G Rao
Published: 202510.1128/aac.00782-25
Abstract
Increased resistance to β-lactams/β-lactamase inhibitors by mutations in β-lactamase genes, porins, and efflux pumps complicates the management of carbapenem-resistant Klebsiella pneumoniae (CRKP). Polymyxin B (PMB)-based combination therapy is the b…
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