Antimicrobial agents and chemotherapy
Characterization of a novel monoclonal antibody candidate that targets bacterial GAPDH and protects neonatal mice from infections caused by Streptococcus pneumoniae or Streptococcus agalactiae.
Carolina Fernandes, Filipa Lemos, Liliana Curado, Bruno L Victor, Maelenn Chevreuil, Inês Machado, Sofia Teixeira, Maria do Carmo Koch, Marta Vieira, Patrick England, Pedro Madureira, Pedro Castanheira
Published: 202610.1128/aac.00666-25
Abstract
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a highly conserved bacterial enzyme essential for glycolysis, yet it also plays important non-metabolic, "moonlighting" roles, including host immunomodulation. Here, we describe the generation and c…
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