Science translational medicineHumansNitrilesPlasmodium falciparumPyrimidinesMalaria
Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum.
Rebecca Webster, Damian A Oyong, Stacey Llewellyn, Azrin N Abd-Rahman, Adam J Potter, Reena Mukhiya, Nischal Sahai, Indika Leelasena, Eniko Ujvary, Sue Mathison, Dean W Andrew, Luzia Bukali, Fabian de Labastida Rivera, Jessica Engel, Megan S F Soon
Published: 202510.1126/scitranslmed.aea2531
Abstract
Inhibiting the inflammatory response to malaria offers a promising strategy to improve clinical outcomes and overcome immunoregulatory barriers that hinder development of antiparasitic immunity. We conducted a double-blind, randomized, placebo-contro…
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