Science translational medicineHumansAtaxia Telangiectasia Mutated ProteinsAnimalsBreast NeoplasmsCell Line
Rb1 deficiency induces synthetic lethality with ATR and PKMYT1 coinhibition in breast cancer cell lines and patient-derived xenografts.
Xiao-Ting Jiang, Mei-Kuang Chen, Jiwang Lee, Xiayu Rao, Yan Wang, Linjie Luo, Jing Wang, Kelly K Hunt, Khandan Keyomarsi
Published: 202510.1126/scitranslmed.adx6797
Abstract
Targeting cell cycle checkpoints has emerged as a promising strategy in cancer therapy, yet single-agent inhibitors often fail because of compensatory mechanisms. Here, we demonstrate that coinhibition of ATR (RP-3500) and PKMYT1 (RP-6306) induces sy…
Preview only. Read the full abstract at the source