Science translational medicineAnimalsInfluenza A VirusH5N1 SubtypeMacaca fascicularisInfluenza Vaccines
A replicating RNA vaccine protects cynomolgus macaques against lethal clade 2.3.4.4b influenza A H5N1 virus challenge.
David W Hawman, Amanda Griffin, Natalie McCarthy, Atsushi Okumura, Shanna S Leventhal, Mahati Agumamidi, Michael Chorabik, Ekaterina Altynova, Matthew Lewis, Troy Hinkley, E Taylor Stone, Nikole Warner, Stephanie Park, Jamie Lovaglio, Brian J Smith
Published: 202510.1126/scitranslmed.adw4646
Abstract
In early 2024, clade 2.3.4.4b highly pathogenic avian influenza (HPAI) A H5N1 virus was detected in United States dairy cattle. Although so far the public health threat of contemporary clade 2.3.4.4b H5N1 virus strains remains low, continued circulat…
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