Science translational medicineAnimalsIon ChannelsHumansProtein Kinase InhibitorsInduced Pluripotent Stem Cells
Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective.
Amit Manhas, Yu Liu, Chikage Noishiki, David Wu, Dipti Tripathi, Sarah Mirza, Dilip Thomas, Lu Liu, Avirup Guha, Patricia K Nguyen, Ian Y Chen, Vipul Chitalia, Paul Cheng, Danish Sayed, Melinda L Telli
Published: 202510.1126/scitranslmed.adv9403
Abstract
Tyrosine kinase inhibitors (TKIs) have improved cancer outcomes but are limited by cardiovascular toxicity, most notably hypertension and heart failure. The underlying mechanisms remain poorly understood, hindering the development of protective strat…
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