Science translational medicineSepsisAnimalsMacrophagesReceptorsIgG
FcγR-targeted tuftsin clusters rejuvenate macrophages in preclinical sepsis-associated secondary infection.
Guangchao Qing, Yuxuan Zhang, Yongchao Wang, Xianlei Li, Ting Luo, Fuxue Zhang, Qiankun Ni, Runjing Hu, Shaobo Shan, Hong Zhang, Rui Yuan, Yaling Gan, Xing-Jie Liang, Yang Luo
Published: 202510.1126/scitranslmed.adv0313
Abstract
Sepsis-associated secondary infection often leads to a high mortality rate. Dysfunctional macrophages are primary contributors to inadequate antimicrobial defense in patients with sepsis-associated immunosuppression. Rejuvenating macrophage antibacte…
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