Science translational medicineAnimalsReceptorsFcHerpes SimplexHumans
Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice.
Matthew D Slein, Iara M Backes, Lesle M Jiménez, Natasha S Kelkar, Callaghan R Garland, Urjeet S Khanwalkar, Anton M Sholukh, Christine Johnston, David A Leib, Margaret E Ackerman
Published: 202510.1126/scitranslmed.adu8579
Abstract
Herpes simplex virus (HSV) encodes surface glycoproteins that are host defense evasion molecules. For example, glycoproteins E and I (gE/gI) form a viral Fc receptor (vFcR) for most subclasses and allotypes of human IgG, promoting evasion of humoral…
Preview only. Read the full abstract at the source