Science translational medicineAnimalsSTAT3 Transcription FactorCarcinogenesisProtein IsoformsPhosphorylation
A hyperactive splice variant of STAT3 promotes colonic inflammation-associated tumorigenesis in mice.
Meng Xu, Dingju Wei, Shu Zhong, Weicheng Liu, Mei Ye, Jie Luo, Shuangdie Zhu, Zhenzhen Lai, Zhiping Zheng, Rui Hu, Qin Chen, Ningning Guo, Jian Lv, Wenmin Tian, Yang Chen
Published: 202510.1126/scitranslmed.adu8484
Abstract
Signal transducer and activator of transcription 3 (STAT3) is essential for cell signaling in response to extracellular stimuli, and its overactivation is a hallmark of inflammation and tumorigenesis. The differential mechanisms underlying the physio…
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