Science translational medicineLupus ErythematosusSystemicToll-Like Receptor 7AnimalsHumans
The m6A demethylase FTO links TLR7 to mitochondrial oxidation driving age-associated B cell formation in systemic lupus erythematosus.
Qin Zeng, Lin Li, Xue Li, Linmang Qin, Tianxiao Feng, Yunfeng Zhu, Jieying Wang, Yaoyao Zou, Jianling Su, Guangfu Dong, Wuzheng Xia, Ting Xu, Guangfeng Zhang, Yang Cui, Haobo Lin
Published: 202510.1126/scitranslmed.adu6015
Abstract
Extrafollicular age-associated B cells (ABCs) excessively expand and produce autoantibodies in systemic lupus erythematosus (SLE), and the regulatory mechanism remains elusive. We found that the m6A demethylase fat mass and obesity-associated protein…
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