Science translational medicineAnimalsNanoparticlesMiceSARS-CoV-2Spike Glycoprotein
Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice.
Grace G Hendricks, Lilit Grigoryan, Mary Jane Navarro, Nicholas J Catanzaro, Miranda L Hubbard, John M Powers, Melissa Mattocks, Catherine Treichel, Alexandra C Walls, Jimin Lee, Daniel Ellis, Jing Yang John Wang, Suna Cheng, Marcos C Miranda, Adian Valdez
Published: 202510.1126/scitranslmed.adu2085
Abstract
Messenger RNA (mRNA) vaccines and computationally designed protein nanoparticle vaccines were both clinically derisked and licensed for the first time during the coronavirus disease 2019 (COVID-19) pandemic. These vaccine modalities have complementar…
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