Science translational medicineAnimalsGlomerulonephritisNeutrophilsGlucocorticoidsCell Differentiation
Low-dose glucocorticoids attenuate crescentic glomerulonephritis by inhibiting the local differentiation of proinflammatory neutrophils.
Junping Yin, Melanie Eichler, Darius P Schaub, Nariaki Asada, Jonas Engesser, Clivia Lisowski, Hans-Joachim Paust, Christina Katharina Weisheit, Jian Li, Daniela Klaus, Natalio Garbi, Sibylle von Vietinghoff, Christian F Krebs, Ulf Panzer, Christian Kurts
Published: 202510.1126/scitranslmed.adu0351
Abstract
Glucocorticoids are widely used to treat autoimmune diseases like crescentic glomerulonephritis (cGN), but their immunosuppressive functions are not fully understood. Here, we generated a single immune cell sequencing atlas at different stages of exp…
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