Science translational medicineHypoxia-Inducible Factor 1alpha SubunitAnimalsTendonsHumans
HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment.
Greta Moschini, Archana G Mohanan, Izabella S Niewczas, Diane E Taylor, Patrick K Jaeger, Guillermo Turiel, Amro A Hussien, Stefania L Wunderli, Olivia Baumberger, Maja Wolleb, Florence Marti, Barbara Niederoest, Maja Bollhalder, Raphaela Ardicoglu, Nathalie Tisch
Published: 202610.1126/scitranslmed.adt1228
Abstract
Tendons are sparsely vascularized connective tissues that link muscles to bones, withstanding some of the highest mechanical stresses in the body. Mechanical overloading and tissue hypervascularity are implicated in tendinopathy, a common musculoskel…
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